NHS-LOGONHS Blood and Transplant (NHSBT) manages the UK national voluntary donation system for blood, tissues, organs and stem cells. NHSBT supply c.2M units of blood a year and last year received 3,500 organ, 4,000 tissue donations and banked 2,200 cord blood units. The Cellular and Molecular Therapies (CMT) Function within NHSBT is responsible for the routine provision of stem cells for transplant across the country and for the development and manufacture of novel advanced cell therapies that fall under MHRA regualtions as ATMPs. CMT operates from eight UK sites, consisting of HTA licensed, JACIE accredited cell processing facilities serving regional BMT programmes and the Clinical Biotechnology Centre at Langford near Bristol preparing DNA plasmids under GMP conditions. This network is supported by integrated infectious disease, bacteriology, red cell immunology, tissue typing, logistics and cold chain supply, Tissue Services and Therapeutic Apheresis Services (TAS), all covered under a single NHSBT Quality Management System (QMS).