NEPHSTROM researchers based at the National University of Ireland, Galway presented two posters on Diabetic Kidney Disease at the recent Irish Endocrine Society 40th Annual Conference in Belfast, Northern Ireland.
In one poster entitled “Influence of chronic kidney disease aetiology on outcomes of multi-disciplinary diabetic renal clinic attendance”, Dr Liam Martin presented evidence that attendance at a multi-disciplinary diabetes renal clinic (DRC) at the Galway University Hospitals improved the rate of loss of kidney function of people with type 2 diabetes and chronic kidney disease. In contrast, those with type 1 diabetes and chronic kidney disease did not have improvement in kidney function loss but did benefit in terms of better blood glucose and cholesterol levels.
In the other poster, entitled “Pilot study of biomarkers in diabetic kidney disease”, Dr Tomás Griffin reported the results of assays for several different biomarkers in serum samples from Galway University Hospital outpatients with mild, moderate and severe diabetic kidney disease. He concluded that serum levels of the proteins leptin, adiponectin, fibroblast growth factor-21 (FGF-21), soluble tumour necrosis factor receptors-1 and 2 (sTNFR-1 and 2), neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-8 (IL-8) correlate with current kidney function and are promising biomarkers for tracking responses to novel therapies during clinical trials such as the forthcoming NEPHSTROM Phase 1b/2a clinical trial of allogeneic Mesenchymal Stem Cells (MSCs) (product ORBCEL M®) in diabetic kidney disease.
The abstracts are published online by the Irish Journal of Medical Sciences (http://link.springer.com/article/10.1007%2Fs11845-016-1482-y).